Webinar • BIO IT: BioPharma Asia Magazine

Employing Hot Melt Extrusion As a Cost Effective Method of Increasing SolubilityAgéndalo en tu calendario habitual ¡en tu horario!

Martes, 7 de mayo de 2019, de 09.00 a 10.00 hs Horario de Virginia (US)
Webinar en inglés

Full Title: Employing Hot Melt Extrusion As a Cost Effective Method of Increasing Solubility Of Water Insoluble API’s • Identifying the appropriate excipients for HME processing of water insoluble drugs • Using novel excipients to achieve increased dissolution rates (Granulation) • Extrusion with polymeric carriers for the development of solid dispersions • Co-crystallisation of water insoluble drugs In the last 20 years Hot Melt Extrusion (HME) has seized the attention of pharmaceutical industry for the development of pharmaceutical solid dispersions. It is a versatile processing technology, which can effectively increase the solubility/dissolution of water insoluble active pharmaceutical ingredients (APIs). The processing of a wide range of materials including inorganic excipients, hydrophilic polymers or cocrystal formers renders HME advantageous compared to conventional formulation technologies. In this review article we discuss recent trends for increased solubility/dissolution of water insoluble actives by using HME and predictive tools for process optimisation.

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